The Role of Gastric Stasis in Tumor-Induced Anorexia in Rats

Document Type

Article

Publication Date

9-1992

Publisher

Wiley

Source Publication

Cancer

Source ISSN

0008-543X

Original Item ID

DOI: 10.1002/1097-0142(19920915)70:6<1601::AID-CNCR2820700626>3.0.CO;2-6

Abstract

Background. The current study was undertaken to determine if changes in gastric emptying contribute to tumor-induced anorexia.

Methods. Rats were implanted with the Walker 256 carcinoma, and food intake was measured daily. On days 0, 8, and 15, the rats were fasted overnight, gavage fed a bolus of liquid food, and residual gastric contents were measured 3 hours later.

Results. Tumor growth was associated with a progressive decline in voluntary food intake. When the rats were gavage fed 2.5 or 7 ml of liquid food, the percent of gastric contents cleared in 3 hours was unchanged with tumor growth.

Conclusions. Changes in gastric emptying did not contribute to decreased food intake with growth of the Walker 256 in rats.

Comments

Cancer, Vol. 70, No. 6 (September 15th, 1992): 1601-1604. DOI.

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