Document Type
Article
Language
eng
Format of Original
8 p.
Publication Date
1-2015
Publisher
Elsevier
Source Publication
American Journal of Obstetrics and Gynecology
Source ISSN
0002-9378
Original Item ID
doi: 10.1016/j.ajog.2014.07.050
Abstract
Objective
To determine whether labor-associated inflammatory markers differ between low-risk, nulliparous women in preactive vs active labor at hospital admission and over time.
Study Design
Prospective comparative study of low-risk, nulliparous women with spontaneous labor onset at term (n = 118) sampled from 2 large Midwestern hospitals. Circulating concentrations of inflammatory markers were measured at admission and again 2 and 4 hours later: namely, neutrophil, and monocyte counts; and serum inflammatory cytokines (interleukin -1β, interleukin-6, tumor necrosis factor-α, interleukin-10) and chemokines (interleukin-8). Biomarker concentrations and their patterns of change over time were compared between preactive (n = 63) and active (n = 55) labor admission groups using Mann-Whitney U tests.
Results
Concentrations of interleukin-6 and interleukin-10 in the active labor admission group were significantly higher than concentrations in the preactive labor admission group at all 3 time points. Neutrophil levels were significantly higher in the active group at 2 and 4 hours after admission. The rate of increase in neutrophils and interleukin-10 between admission and 2 hours later was faster in the active group (P < .001 and P = .003, respectively).
Conclusion
Circulating concentrations of several inflammatory biomarkers are higher and their rate of change over time since admission is faster among low-risk, nulliparous women admitted to hospitals in active labor, as compared with those admitted in preactive labor. More research is needed to determine if progressive changes in inflammatory biomarkers might be a useful adjunct to improving the assessment of labor progression and determining the optimal timing of labor admission.
Recommended Citation
Neal, Jeremy L.; Lamp, Jane M.; Lowe, Nancy; Gillespie, Shannon L.; Sinnott, Loraine T.; and McCarthy, Donna O., "Differences in Inflammatory Markers between Nulliparous Women Admitted to Hospitals in Preactive vs Active Labor" (2015). College of Nursing Faculty Research and Publications. 356.
https://epublications.marquette.edu/nursing_fac/356
Comments
Accepted version. American Journal of Obstetrics and Gynecology, Vol. 212, No. 1 (January 2015): 68.e1–68.e8. DOI. © 2015 Elsevier Inc. Used with permission.