Document Type

Article

Language

eng

Format of Original

11 p.

Publication Date

4-2015

Publisher

SAGE Publications

Source Publication

Western Journal of Nursing Research

Source ISSN

0193-9459

Original Item ID

doi: 10.1177/0193945914545658

Abstract

Chronic psychological stress impairs antibody synthesis following influenza vaccination. Chronic stress also increases circulating levels of proinflammatory cytokines and glucocorticoids in elders and caregivers, which can impair antibody synthesis. The purpose of this study was to determine whether psychological stress increases ex vivo cytokine production or decreases glucocorticoid sensitivity (GCS) of peripheral blood leukocytes from healthy college students. A convenience sample of Reserve Officer Training Corps (ROTC) students completed the Perceived Stress Scale (PSS). Whole blood was incubated in the presence of influenza vaccine and dexamethasone to evaluate production of interleukin-6 (IL-6), interleukin-1-beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ). Multiple regression models controlling for age, gender, and grade point average revealed a negative relationship between PSS and GCS for vaccine-stimulated production of IL-1β, IL-6, and TNF-α. These data increase our understanding of the complex relationship between chronic stress and immune function.

Comments

Accepted version. Western Journal of Nursing Research, Vol. 37, No. 4 (April 2015): 483-493. DOI. © 2015 by SAGE Publications. Used with permission.

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