Recommendations for The Conduct of Economic Evaluations in Osteoporosis: Outcomes of An Experts’ Consensus Meeting Organized by The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) And the US Branch of The International Osteoporosis Foundation

Authors

M. Hiligsmann, Maastricht UniversityFollow
J.-Y. Reginster, King Saud UniversityFollow
A.N.A. Tosteson, Geisel School of Medicine at Dartmouth
S.V. Bukata, UCLA Orthopaedic Center
K.G. Saag, University of Alabama at Birmingham
D.T. Gold, Duke University Medical Center
P. Halbout, International Osteoporosis FoundationFollow
F. Jiwa, Osteoporosis CanadaFollow
E.M. Lewiecki, New Mexico Clinical Research & Osteoporosis Center
Daniel Pinto, Marquette UniversityFollow
J.D. Adachi, McMaster University
N. Al-Daghri, King Saud UniversityFollow
O. Bruyère, University of LiègeFollow
M. Chandran, Singapore General Hospital
C. Cooper, University of SouthamptonFollow
N.C. Harvey, University of Southampton
T.A. Einhorn, New York University Langone Health
J.A. Kanis, University of SheffieldFollow
D.L. Kendler, University of British Columbia
O.D. Messina, Cosme Argerich Hospital
R. Rizzoli, Geneva University HospitalsFollow
L. Si, University of New South Wales
S. Silverman, UCLA School of Medicine

Document Type

Article

Language

eng

Publication Date

1-2019

Publisher

Springer

Source Publication

Osteoporosis International

Source ISSN

0937-941X

Abstract

Summary

Economic evaluations are increasingly used to assess the value of health interventions, but variable quality and heterogeneity limit the use of these evaluations by decision-makers. These recommendations provide guidance for the design, conduct, and reporting of economic evaluations in osteoporosis to improve their transparency, comparability, and methodologic standards.

Introduction

This paper aims to provide recommendations for the conduct of economic evaluations in osteoporosis in order to improve their transparency, comparability, and methodologic standards.

Methods

A working group was convened by the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis to make recommendations for the design, conduct, and reporting of economic evaluations in osteoporosis, to define an osteoporosis-specific reference case to serve a minimum standard for all economic analyses in osteoporosis, to discuss methodologic challenges and initiate a call for research. A literature review, a face-to-face meeting in New York City (including 11 experts), and a review/approval by a larger group of experts worldwide (including 23 experts in total) were conducted.

Results

Recommendations on the type of economic evaluation, methods for economic evaluation, modeling aspects, base-case analysis and population, excess mortality, fracture costs and disutility, treatment characteristics, and model validation were provided. Recommendations for reporting economic evaluations in osteoporosis were also made and an osteoporosis-specific checklist was designed that includes items to report when performing an economic evaluation in osteoporosis. Further, 12 minimum criteria for economic evaluations in osteoporosis were identified and 12 methodologic challenges and need for further research were discussed.

Conclusion

While the working group acknowledges challenges and the need for further research, these recommendations are intended to supplement general and national guidelines for economic evaluations, improve transparency, quality, and comparability of economic evaluations in osteoporosis, and maintain methodologic standards to increase their use by decision-makers.

Comments

Accepted version. Osteoporosis International, Vol. 30, No. 1 (January 2019) : 45-57. DOI. © 2019 Springer. Used with permission.

Recommended Citation

Hiligsmann, M.; Reginster, J.-Y.; Tosteson, A.N.A.; Bukata, S.V.; Saag, K.G.; Gold, D.T.; Halbout, P.; Jiwa, F.; Lewiecki, E.M.; Pinto, Daniel; Adachi, J.D.; Al-Daghri, N.; Bruyère, O.; Chandran, M.; Cooper, C.; Harvey, N.C.; Einhorn, T.A.; Kanis, J.A.; Kendler, D.L.; Messina, O.D.; Rizzoli, R.; Si, L.; and Silverman, S., "Recommendations for The Conduct of Economic Evaluations in Osteoporosis: Outcomes of An Experts’ Consensus Meeting Organized by The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) And the US Branch of The International Osteoporosis Foundation" (2019). Physical Therapy Faculty Research and Publications. 168.
https://epublications.marquette.edu/phys_therapy_fac/168