Document Type
Article
Publication Date
2025
Publisher
Frontiers Media S.A.
Source Publication
Frontiers in Aging Neuroscience
Source ISSN
1663-4365
Original Item ID
DOI: 10.3389/fnagi.2025.1568500
Abstract
With the rapid increase in the aging population, the prevalence of age-related neurodegenerative diseases such as Alzheimer's disease (AD) has risen significantly, affecting over 55 million people worldwide in 2023, with projections suggesting this number will exceed 78 million by 2030 (Better, 2023). While much research has been focused on understanding and treating AD in older adults, there is growing emphasis on early interventions to prevent its onset (Crous-Bou et al., 2017; Dohm-Hansen et al., 2024). In this regard, middle-age has gained recognition as a critical period for the development and prevention of AD (Ritchie et al., 2017). For example, midlife vascular risk factors including diabetes, obesity, and hypertension increased the risk of developing AD in late life (Livingston et al., 2020). This Research Topic includes eight human and rodent studies, including three review papers, exploring strategies to reduce the risk of age-related cognitive decline and mechanisms of age-related memory decline in middle-aged individuals, older adults with normal cognition, those with mild cognitive impairment (MCI), and those with AD.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Won, Junyeon; Gogniat, Marissa A.; Kurazumi, Takuya; and Nielson, Kristy A., "Editorial: Midlife Brain Health: Understanding Brain Aging in Middle-Age and Effects of Interventions to Prevent Neurodegeneration in Late Life" (2025). Psychology Faculty Research and Publications. 598.
https://epublications.marquette.edu/psych_fac/598
Comments
Published version. Frontiers in Aging Neuroscience, Vol. 17 (2025). DOI. © 2025 Won, Gogniat, Kurazumi and Nielson.
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