Document Type
Article
Publication Date
7-30-2025
Publisher
Wiley
Source Publication
Human Brain Mapping
Source ISSN
1065-9471
Original Item ID
DOI: 10.1002/hbm.70116
Abstract
Using functional magnetic resonance imaging (fMRI), symptoms of posttraumatic stress disorder (PTSD) have been associated with aberrations in brain networks in the absence of a given cognitive demand or task, called resting-state networks. Prior work has focused on disruption in the static functional connectivity (FC) among specific regions constrained by a priori hypotheses. However, dynamic FC, an approach that examines brain network characteristics over time, may provide a more sensitive measure to understand the network properties underlying dysfunction in PTSD. Further, using a data-driven analytic approach may reveal the contribution of other larger network disturbances beyond those revealed by hypothesis-driven examinations of ROIs or canonical networks. Therefore, the current study used group independent components analysis (ICA) and graph theory principles to identify, characterize, and subsequently compare brain network dynamics and recurrent connectivity states in a large sample of trauma exposed individuals (N = 1035) with and without PTSD from the ENIGMA-PGC PTSD workgroup. Neither static FC nor dynamic FC results showed robust differences between groups. There were also no group differences in dwell time or number of transitions of recurrent connectivity states. This multi-cohort sample with heterogenous trauma types and demographic features offers a significantly larger scale approach than prior literature with smaller homogenous trauma cohorts. Heterogeneity of PTSD, especially within diffuse brain networks, may not be captured by evaluating only diagnostic groups, further work should be done to evaluate brain network dynamics with respect to specific symptom profiles and trauma types.
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Recommended Citation
Fitzgerald, Jacklynn M., "Data-Driven Approach to Dynamic Resting State Functional Connectivity in Post-Traumatic Stress Disorder: An ENIGMA-PGC PTSD Study" (2025). Psychology Faculty Research and Publications. 635.
https://epublications.marquette.edu/psych_fac/635
Comments
Published version. Human Brain Mapping, Vol. 46, No. 11 (July 30, 2025). DOI. © 2025 The Author(s). Human Brain Mapping published by Wiley Periodicals LLC.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.