Date of Award
Summer 1966
Document Type
Thesis - Restricted
Degree Name
Master of Science (MS)
Department
Chemistry
First Advisor
Vercellotti, John R.
Second Advisor
Hoffman, Norman
Third Advisor
Bournique, Raymond A.
Abstract
Glycoprotein and mucoprotein chemistry is and has been a subject of extensive interest and research. It is the purpose of this writing to describe the synthesis of a model compound, an 0-glycoside of an hydroxy amino acid, which as a postulate, forms a protein-to-carbohydrate linkage in glycoor mucoproteins. The 0-glycosides of suitably blocked 4-hydroxyproline and 2-amino-2-deoxy-D-glucopyranose (R-glucosamine) are one of a series of 0-glycosides of hydroxy-amino acids being synthesized and investigated by Dr. John R. Vercellotti of the department of chemistry of Marquette University. It is the premise of Dr. Vercellotti that an electron withdrawing group, such as the,2,4-dinitrophenyl group, linked to the amino function of the amino acid moiety in the Q-glycoside might simulate enzyme-substrate activity in the acid and base catalyzed hydrolysis of the 0-glycoside. It is hoped that the products of the hydrolysis of such suitably substituted and blocked 0-glycosides might provide basic information about the reactions of carbohydrates in i glycoproteins and their characterization.
Recommended Citation
Just, Ernst Karl, "Synthesis of an O-Glycoside of Hydroxyproline" (1966). Master's Theses (1922-2009) Access restricted to Marquette Campus. 2541.
https://epublications.marquette.edu/theses/2541