Date of Award
Spring 1962
Document Type
Thesis - Restricted
Degree Name
Master of Science (MS)
Department
Nursing
Abstract
Insulin induced hypoglycemia below a critical blood level of fifty mg. percent results in gastric acid stimulation in the intact human stomach or as simulated in the laboratory by the innervated stomach (Pavlov) pouch dog. This gastric response fails to occur if the vagi are severed as in a denervated stomach (Heidenhain) pouch dog. Therefore, it is generally concluded that this gastric acid stimulation by insulin is a central nervous system reflex mechanism mediated through the vagi when the blood sugar drops below the critical level of fifty mg. percent, and is not a direct action of the insulin itself. With the recent availability of potent non-insulin synthetic hypoglycemic agents, such as chlorpromamide* [sic] and tolbutamide,** there was once again an opportunity to closely investigate this poorly understood physiological phenomena.
Recommended Citation
Polacek, Michael A., "An Observation of the Mechanism of Insulin Induced Stimulation of Gastric Acid Secretions" (1962). Master's Theses (1922-2009) Access restricted to Marquette Campus. 3675.
https://epublications.marquette.edu/theses/3675