Date of Award

Spring 1993

Document Type

Thesis - Restricted

Degree Name

Master of Science (MS)

Department

Biomedical Engineering

First Advisor

Boerboom, Lawrence

Abstract

This thesis details the development of a microprocessor-based coronary perfusion system used to enable studies of coronary circulation that are independent of the influence of the systemic circulation. A closed loop servo valve system is used to control coronary perfusion. The servo valve serves to partition blood flow between a coronary cannula and a recirculating circuit. Chapter I introduces the thesis objective and provides an outline of the thesis. The objective of the thesis is to 1) develop a level control mechanism for the blood reservoirs used by the perfusion system, 2) evaluate the frequency response characteristics of the perfusion system, and 3) determine the influence of blood supply pressure on the flow of the servo valve through the return circuit. Chapter II describes the main components of the perfusion system. It also details the issues investigated to evaluate the performance of the perfusion system namely, the influence of supply pressure on servo valve frequency response, the influence of individual components on frequency response of the perfusion system assembly, the relationship between supply pressure and return flow of the servo valve, the system ability to reproduce nonsinusoidal reference signals, and the performance of the perfusion system in an application in which it was used to perfuse the total left coronary circulation in a dog. Chapter III examine the results obtained from evaluating the level control system, the frequency response of the perfusion system, and the influence of supply pressure on return flow of the servo valve. Chapter IV discusses the perfusion system's performance and capabilities. Suggestions for future studies are also presented in this chapter.

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