Date of Award

Summer 1963

Document Type

Thesis - Restricted

Degree Name

Master of Science (MS)

Department

Chemistry

Abstract

The metal chelating agent, 2-thenoyltrifluoroacetone, known also as TTA, has been successfully used in the radiochemical analysis of metal ions. Separations and determinations of fission products have been effected by the use of this versatile chelating agent. At present it is regarded as the most highly selective extractant for metal ions such as: zirconium, cerium, neptunium, iron, plutonium and several others, and offers many applications to separations of these metals ions. Iron(III) ion was found to be one of the many metals which can be extracted quantitatively with TTA in an organic solvent. In an earlier work by Noore, Fairman, Ganchoff and Surak (24) it was found that extraction of iron(III) ion from a 10M nitric acid solution with TTA-xylene system was very efficient and very highly selective. The object of this research is to study the possibility of adapting the method to the spectrophotometric determination of iron found in biological materials with particular emphasis on the iron content of blood. The classical gravimetric and titrimetric methods of analyses are not too practical for the determination of iron in biological materials because it is present in only minute amounts. Methods involving the reaction of iron with chromogenic reagents are extensively used in biological and in clinical analyses. Interest in the determination of iron in biological materials has been aroused by the recognition of its importance in medical diagnosis of diseases affecting the metabolism of iron. Research is now directed towards the development of simple, rapid and reliable methods suitable for routine clinical analysis.

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