Date of Award

Spring 1996

Document Type

Thesis - Restricted

Degree Name

Master of Science (MS)

Department

Biomedical Engineering

First Advisor

Clough, Anne V.

Second Advisor

Linehan, John H.

Abstract

Chapter 1 provides an introduction to the thesis and a literature review. This review describes previously used methods for the determination of pulmonary flow, volume and mean transit time from indicator curves. Results of these studies are cited. Chapter 2 contains a description of the experiments from which the data used in this study were taken. Experimental setup, procedure and data recording are discussed. The transition from video data to intensity curves is described in this chapter, as well as, the calibration and the methods used to verify the consistency of the curves. Chapter 3 describes the procedure used to convert the intensity data into absorbance data, and the calculations used to obtain flow, volume and mean transit time. Calculation of blood flow, volume and mean transit time by direct deconvolution of the recorded arterial and microvascular curve data and the calculation of mean transit time using curve fitting is described. Chapter 4 presents the results obtained from experimental data. Chapter 5 is a discussion of the strength of the model and the physiological significance of the results reported in chapter 4. Chapter 6 contains the conclusions and suggested future work arising from this study.

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