Date of Award
Fall 2005
Document Type
Thesis - Restricted
Degree Name
Master of Science (MS)
Department
Biomedical Engineering
First Advisor
Olson, Lars E.
Second Advisor
Karanian, John W.
Third Advisor
Pritchard, William F.
Abstract
Over the past decade, percutaneous coronary interventions such as balloon angioplasty and stents have been largely used to treat arterial diseases. During percutaneous interventions, the artery is stretched, disrupting the endothelial cells that line the artery. This disruption initiates a healing response that may have a major influence on the degree of neointimal hyperplasia, or vascular smooth muscle proliferation. Recent studies have shown that local delivery of drugs with anti-restenotic properties aid re-endothelialization and prevent proliferation of smooth muscle cells. The pharmacokinetics of locally delivereo pharmacological agents depends on various factors such as the physiochemical properties of the drug and mode of delivery. This thesis compares the pharmacokinetic properties and effectiveness of endoluminal and perivascular delivery of a drug in an in vitro vascular flow model. Additionally, this thesis also examines the in vitro tissue distribution and transport kinetics of locally delivered hydrophilic drug, which may be used to develop a predictive model for evaluation of locally delivered therapeutics.
Recommended Citation
Shah, Ankit Dilip, "Development of An in Vitro Vascular Flow Model to Determine the Pharmacokinetics of Locally Delivered Therapeutics: A Comparison of Drug Physiochemical Properties and Modes of Delivery" (2005). Master's Theses (1922-2009) Access restricted to Marquette Campus. 4131.
https://epublications.marquette.edu/theses/4131