Date of Award

Fall 2005

Degree Type

Thesis - Restricted

Degree Name

Master of Science (MS)

Department

Biomedical Engineering

First Advisor

Olson, Lars E.

Second Advisor

Karanian, John W.

Third Advisor

Pritchard, William F.

Abstract

Over the past decade, percutaneous coronary interventions such as balloon angioplasty and stents have been largely used to treat arterial diseases. During percutaneous interventions, the artery is stretched, disrupting the endothelial cells that line the artery. This disruption initiates a healing response that may have a major influence on the degree of neointimal hyperplasia, or vascular smooth muscle proliferation. Recent studies have shown that local delivery of drugs with anti-restenotic properties aid re-endothelialization and prevent proliferation of smooth muscle cells. The pharmacokinetics of locally delivereo pharmacological agents depends on various factors such as the physiochemical properties of the drug and mode of delivery. This thesis compares the pharmacokinetic properties and effectiveness of endoluminal and perivascular delivery of a drug in an in vitro vascular flow model. Additionally, this thesis also examines the in vitro tissue distribution and transport kinetics of locally delivered hydrophilic drug, which may be used to develop a predictive model for evaluation of locally delivered therapeutics.

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