Date of Award
Fall 2005
Document Type
Thesis - Restricted
Degree Name
Master of Science (MS)
Department
Biomedical Engineering
First Advisor
Jeutter, Dean
Second Advisor
Wang, Xujing
Third Advisor
Audi, Said
Abstract
Since its first introduction in 1979 by Bergman et al, Minimal Model (MINMOD) has become an important research tool in the investigation of glucose regulation. It has provided insight into the secretion and action of insulin and the effectiveness of glucose itself in regulating glucose tolerance. More than 500 research papers have been published since, reporting experimental results and MlNMOD analyses in humans and dogs. Because insulin resistance and impaired glucose effectiveness contribute to the patho-physiology of Non Insulin-Dependent Diabetes Mellitus (NIDDM or Type 2 Diabetes (T2D)), a quantitative assessment of these properties is of utmost importance. As a consequence, MINMOD has been very frequently applied to analyze FSIVGTT (Frequently Sampled Intravenous Glucose Tolerance Test) data of T2D subjects and great success has been achieved. In particular the Disposition Index (DD derived using MINMOD has been found to be an excellent prognostic marker for T2D. However, very few studies have been carried out to quantify the effects of insulin and glucose in glucose regulation in Type I Diabetes (TlD) subjects. Although glucose utilization is impaired in TID subjects, it is unclear whether this is due to reductions in Insulin Sensitivity (Si) and/or glucose-mediated glucose disposal (SG). TID subjects lacked endogenous insulin secretion and any experimental protocol involved in the study of individual contributions of glucose and insulin in these subjects involves risk. During the course of these studies, MINMOD has come under criticism that it is under-modeled due to the assumption of single compartment of glucose, and that this led to the overestimation of SG in subjects with impaired insulin secretion. Our long term goal is to develop a robust model of B-cell (pancreatic cell that secrets insulin) mass and functionality coupled with MINMOD. As a first step in this thesis project, we set to resolve the problems in MINMOD, evaluate the known reports on TlD subjects, examine the reasons for discrepancies and implement MINMOD in Matlab.
Recommended Citation
Nittala, Aparna, "Estimation of Glucose-Mediated Glucose Disposal in Type 1 Diabetic Subjects using MINMOD" (2005). Master's Theses (1922-2009) Access restricted to Marquette Campus. 4661.
https://epublications.marquette.edu/theses/4661