Date of Award

Fall 1985

Document Type

Thesis - Restricted

Degree Name

Master of Science (MS)

Department

Biomedical Engineering

First Advisor

Linehan, John H.

Second Advisor

Petrie, Thomas

Third Advisor

Elkouh, Abdel

Abstract

This thesis deals with the computer simulation of the static and the dynamic responses of the cat lung. Detailed morphometric and elasticity data for the different generations of blood vessels have been used to determine the hemodynamic resistance and the compliance for each generation. The static model developed on this basis has been extended to successfully simulate the dynamic responses. Chapter 1 details the experimental methods used and introduces the static experiments. The discussion on the static experiments provides insight into the results obtained. Chapter 2 describes the development of the static model from the detailed morphometric and elasticity data available for the cat lung. The static model predictions are compared with the data obtained from the laboratory. Chapter 3 introduces and describes the dynamic experiments. An attempt has been made to explain the dynamic behavior of the lung on the basis of an electrical analog with resistors and capacitors to represent the hemodynamic resistance and compliance respectively. Chapter 4 presents the development of an electrical analog to model the dynamic responses of the cat lung. The methods used in modelling the responses are presented. Chapter 5 discusses the results, the successes and shortcomings of all the dynamic models. The deviations of the model predictions from the data are discussed and the model is modified accordingly. Chapter 6 lists the experimental observations and discusses the adequacy of the final model, i.e., model 4. A comparison between the original Zhuang model and model 4 is also provided.

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