Date of Award
Spring 1988
Document Type
Thesis - Restricted
Degree Name
Master of Science (MS)
Department
Dentistry
First Advisor
Ferguson, Donald J.
Second Advisor
Meyer, Ralph A.
Third Advisor
Cheek, John G.
Abstract
The purpose of this study was to determine whether the local submucosal injection of osteoclast activators such as prostaglandin E2 (PGE2) or L- thyroxine (T4) could increase the rate of orthodontic tooth movement in guinea pigs. Also, the objective was to evaluate whether or not the effects of the local administration of such osteoclast activators remain localized or are manifested at sites distant from the area of injection. Additionally, the intent was to search for possible adverse systemic side effects as measured by a drop in body weight. as well as to evaluate the effect of prostaglandin Ez and L-thyroxine on bone morphology and cemental root surface topography. Orthodontic appliances were placed on the maxillary and mandibular incisors of 30 male Hartley guinea pigs (10 control, 10 PGEz treated, 10 T4 treated). During the experiment, suspensions of prostaglandin E2. L-thyroxine, and a control suspension were injected submucosally on the lateral bone surface of each maxillary incisor of the corresponding groups. The animals injected with prostaglandin E2 and L-thyroxine showed significantly increased rates of tooth movement in the maxilla when compared to the control. There was no significant difference in the rates of tooth movement for the mandibular incisors. Also, there was no significant difference with respect to body weight or root surface topography, and the general histologic picture was one of a normal response to orthodontic forces.
Recommended Citation
Kalange, John T., "The Effect of Prostaglandin E2 and L-Thyroxine on Experimental Orthodontic Tooth Movement in Cavia Porcellus" (1988). Master's Theses (1922-2009) Access restricted to Marquette Campus. 5408.
https://epublications.marquette.edu/theses/5408