Date of Award
2000
Document Type
Thesis - Restricted
Degree Name
Master of Science (MS)
Department
Dentistry
First Advisor
Ellinger, Royal
Second Advisor
Dentino, Andrew
Third Advisor
Oyen, Ordean J.
Abstract
Adult periodontitis is a disease associated with subgingival bacterial accumulation. Treatment for adult periodontitis aims at the elimination of these harmful microbes. The current study looks at a different approach to a common problem, the elimination and/or control of periodontal pathogens. Due to the fact that periodontitis is a bacterial driven disease, antibiotics seem a logical solution. Systemic administration of antibiotics has been and continues to be used as an adjunctive form of treatment for refractory periodontitis, or, in other words, a periodontal disease which continues to progress despite the use of the aforementioned treatment modalities. Systemic antibiotics lack the ability to purely focus on the periodontium and may lead to systemic complications such as host resistance and/or an interference with oral contraception. With these possible complications in mind there has been a great effort to use a localized form of antimicrobial therapy which would concentrate the use of the antibiotic in the desired area such as the periodontium. The present study looks at one such localized delivery drug. This drug is a polymer which is injected into an affected site and contains the antibiotic doxycycline for the reduction and hopeful elimination of the bacteria present in a periodontally involved site. Each patient presented with at least two teeth treatment planned for extraction either due to periodontal disease or esthetics. These teeth were then either root planed, treated with the polymer, and extracted after seven or twenty-eight days or not root planed, but treated with the polymer, and extracted after seven or twenty-eight days. There were also some teeth that were not treated at all, butt used as controls. These teeth were then evaluated microscopically for adsorption. and/or penetration. The issue to be addressed in this study will be the presence of the drug under four different conditions. This study looked at the penetration of doxycycline into root planed and non-root planed teeth at seven and at twenty-eight days after administration.
Recommended Citation
Weaver, Adam Fred, "The Penetration of Doxycycline into Periodontally Diseased Root Surfaces Following Treatment with a Doxycycline-Releasing Polymer" (2000). Master's Theses (1922-2009) Access restricted to Marquette Campus. 5447.
https://epublications.marquette.edu/theses/5447