Date of Award
11-1953
Document Type
Thesis - Restricted
Degree Name
Master of Science (MS)
Department
Biological Sciences
First Advisor
Armand J. Quick
Second Advisor
M. Laskowski
Third Advisor
Scott L. Kittsley
Abstract
Plasma contains three major proteins: albumin, globulin, and fibrinogen. Even though fibrinogen, which is also present in other body fluids such as lymph, is found in smaller concentrations than the other two, it possesses many important properties, such as regulation of the viscosity in blood, and its convertability to insoluble fibrin when the enzyme thrombin acts on it. Fibrin was recognized in 'l666 by Malpighi when he noticed that a mass of white fibers remains when clotted blood is washed. Ruysch, in 1707, noticed a similar mass of white fibers by whipping the blood. In 1859, Dennis precipitated plasma, rendered incoagulable by the addition of one seventh of its volume of sodium sulfate, by saturating it with sodium chloride. He dissolved the precipitated gelatinous mass in water and noted that it coagulated at room temperature forming fibrin and leaving a protein in solution, thereby showing that fibrin came from a soluble protein in plasma. Alexander Schmidt, in 1861. - 1862, passed carbon dioxide through diluted plasma and noticed the formation of two protein precipitates which he named fibrinogen and paraglobulin. The first., however, to clearly state the mechanism of the formation of fibrin when blood clotted was. Hammarsten, 1877 - 1879, who concluded that coagulation is brought about by the action of thrombin on fibrinogen.
Recommended Citation
Georgatsos, John G., "Studies on a Fibrinogen Stimulating Factor Associated with Neutrophiles" (1953). Master's Theses (1922-2009) Access restricted to Marquette Campus. 5602.
https://epublications.marquette.edu/theses/5602