Date of Award
4-1967
Document Type
Thesis - Restricted
Degree Name
Master of Science (MS)
Department
Medical
First Advisor
Walter P. Blount
Second Advisor
Ross C. Kory
Third Advisor
Karl H. Mueller
Abstract
Runt disease is an experimental generalized autoimmune disease. It can be produced in laboratory animals with ease and predictability. The disease is produced by placing an immunologically competent graft on a host that can stimulate the reactivity of the graft but is unable to reject the graft. This results in destruction of the host by the graft in the same manner that homografted tissues are destroyed by competent hosts. The characteristic pathologic features are lack of growth, emaciation, anemia, and lymphoid atrophy (29).
The possibility of this occurring in humans has been emphasized in a recent article by Hathaway, et al. (17) in which immunologically deficient children we re given multiple £re sh blood transfusions. Two children were discussed and both developed changes similar to those seen in experimental runt disease.
The main emphasis on runt disease has been in the opportunity it affords to study the results of a generalized immunologic attack on an otherwise normal animal. The mechanisms of tissue destruction and the cells responsible for this have been investigated (29).
Recommended Citation
Gore, Donald, "Skeletal Manifestations in Runt Disease" (1967). Master's Theses (1922-2009) Access restricted to Marquette Campus. 5607.
https://epublications.marquette.edu/theses/5607