Date of Award

8-1966

Document Type

Thesis - Restricted

Degree Name

Master of Science (MS)

Department

Medical

First Advisor

James J. Smith

Second Advisor

Howard M. Klitgaard

Abstract

The reticuloendothelial system (RES) is made up of a structurally depressed but functionally similar collection of cells. The role of the RES as the defense mechanism against pathogenic invaders has been well established. More recently, the RES has been shown to be involved in the bodily response to other types of stress, e.g. traumatic and hemorrhagic shock. Although the functional aspects of the RES have been extensively investigated, the existence of an intrinsic regulatory mechanism of such a system has not been clearly demonstrated. Since certain hormones are known to affect the RES, it seemed possible that this system may be under hormonal control.

Earlier studies have indicated a relationship between the RES and the hypophysis. Using a variety of methods for testing the phagocytic activity of the RES, past investigators found different results following hypophysectomy. Seemingly contradictory results have also been reported concerning the effect of RES stimulants after hypophysectomy.

The studies reported in this thesis are an attempt (1) to investigate the long term effects of hypophysectomy on the ability of the animals reticuloendothelial system to clear colloidal carbon from its blood stream and (2) to resolve the differences concerning zymosan stimulation in hypophysectomized animals.

Comments

Page 37 is missing.

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