Date of Award
5-1967
Document Type
Thesis - Restricted
Degree Name
Master of Science (MS)
Department
Medical
First Advisor
David W. Glenister
Second Advisor
Lyle Hamilton
Third Advisor
Howard M. Klitgaard
Abstract
In the last decade heparin has been documented to have a nutriuretic action due to an inhibition of aldosterone secretion (Majoor et al., 1960). However, little light had been shed on the mechanism by which heparin acts until an isolated case report (Wilson and Goetz, 1964) gave evidence that chronic heparin treatment in man resulted in hypoplasia of the zona glomerulosa of the adrenal cortex. If such a result would be the case in a series of patients treated with heparin; then apparently heparin must inhibit aldosterone secretion in a different manner than the adrenal cellular inhibitors which cause hyperplasia of the adrenal gland (Hertz et al., 1955; Adlin and Channick, 1966).
Since such an experiment would not be feasible in man, it was decided that the rat would be the most appropriate animal because of the clear delineation of cortical zones in its adrenal (Marx and Deane, 1963).
The present investigation describes the end effect of heparin administration throughout a three week period of sodium-deprivation (Na-deprivation). A review of the control system of aldosterone is presented in the introduction to help clarify the results and the final discussion thereof.
Recommended Citation
Humpert, Edward L., "Effects of Heparin on the Adrenal Cortex in the Rat" (1967). Master's Theses (1922-2009) Access restricted to Marquette Campus. 5682.
https://epublications.marquette.edu/theses/5682