Date of Award
1-1963
Document Type
Thesis - Restricted
Degree Name
Master of Science (MS)
Department
Medical
First Advisor
Howard M. Klitgaard
Second Advisor
Alvin F. Rieck
Third Advisor
William J. Stekiel
Abstract
Malic dehydrogenase (MDH) capacity in rat heart tissue homogenates and mitochondrial suspensions shows a 75% reduction when 4.5 x 10-5 M thyroxine is added in vitro (1). Thyroxine was found to inhibit other DPN-linked dehydrogenases in vitro, namely, glutamic, lactic, triosphosphate, yeast alcohol, and yeast glucose-6-phosphate dehydrogenases (2). The present study involves an evaluation of the changes of MDH activity in vivo with time due to thyroxine lack after thyroidectomy. In addition, the correlation of enzyme changes with the decline in tissue oxygen · consumption during similar time periods after surgical removal of the thyroid gland was performed.
Recommended Citation
Benson, Samuel G., "Changes in Malic Dehydrogenase Capacities in Excised Rat Tissues After Thyroidectomy" (1963). Master's Theses (1922-2009) Access restricted to Marquette Campus. 5724.
https://epublications.marquette.edu/theses/5724