Date of Award

5-1952

Document Type

Thesis - Restricted

Degree Name

Master of Science (MS)

Department

Medical

First Advisor

Albert G. Schutte

Second Advisor

Walter Zeit

Third Advisor

Samuel B. Pessin

Abstract

The author of this paper first became interested in familial multiple polyposis when he saw his first case while in the United States Navy Medical Corps, at the Great Lakes Hospital, in 1945. He next saw two cases during the course of his post graduate study at the Milwaukee County Hospital and the Graduate School at Marquette University, when he had the opportunity of studying a case from each of two different families with this interesting disease. After getting careful medical histories on both of these patients, he found that several members of each family bad a similar disease or had symptoms of this disease.

During the last five years, he had an opportunity to study members of both of these families and, in addition, a third family was uncovered.

In reviewing the literature, it was found that Menzel, in 1721, described the first case of "polyposis". (Dukes feels that this case was very probably a pseudo polyposis.) Since that time, numerous articles have been written describing this disease in one or several members of a family. It has been of keen interest to study these families and to find that the disease is following a rather definite pattern.

This author has studied the literature from Menzel's time, in 1721, to the present date. Many articles have been written on the diagnosis and the therapy of this disease, but comparatively little has been written on the hereditary factors.

It is the purpose of the author to present: the relationship of the disease to inheritance; the relationship of the disease to male and female; the relationship of the disease to carcinoma; and the method of transmission exhibited by the characteristics of the disease.

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