"Phospholipid Kinetics in the Isolated Perfused Dog Kidney and in the H" by Thomas W. Sneider

Date of Award

8-1963

Document Type

Thesis - Restricted

Degree Name

Master of Science (MS)

Department

Biological Sciences

First Advisor

Moris L. Shore

Second Advisor

Lyle H. Hamilton

Abstract

Since the late 19th century, innumerable workers have focused their attention upon the biochemistry and physiology of the phosphoruscontaining lipids. Although much progress has been made in elucidating the chemical structures, properties and reactions of the phospholipids, the precise functions and degree of participation in the bodily economy played by the phospholipids remains to be delineated. Since phospholipids are known to occur in the plasma, and since it is known that they cannot be synthesized there, the plasma phospholipids have been intensively studied as reflections of phospholipid metabolism within the tissues. It has been held, however, that plasma phospholipids are synthesized and utilized only by the liver. If this is indeed the case, then the plasma phospholipids reflect only hepatic phospholipid metabolism. Conversely, if plasma phospholipids are synthesized and utilized by extra-hepatic tissue as well, then the study of plasma phospholipids would be more complex but would -- potentially -- yield more information about general phospholipid metabolism. These investigations are an attempt to define the presence or absence of extra- hepatic tissue participation in plasma tissue phospholipid metabolism. If such participation is demonstrable, the nature and rates of the extra-hepatic involvement will be studied.

Comments

A Thesis submitted to the Faculty of the Graduate School, Marquette University in Partial Fulfillment of the Requirements for the Degree of Master of Science, Milwaukee, Wisconsin

Download

Share

COinS

Restricted Access Item

Having trouble?