Date of Award

4-1971

Document Type

Thesis - Restricted

Degree Name

Master of Science (MS)

Department

Biological Sciences

First Advisor

S.E. Grossberg

Second Advisor

B.W. Catlin

Third Advisor

B.A. Brown

Abstract

The golden Syrian hamster, (Mesocricetus auratus) has been shown to be highly susceptible to virus infections. Kilham and Overman (1953) reported that mumps virus, which usually produces a mild disease in man and which is not fatal to monkeys or to embryonated eggs in early passages, produces fatal encephalitis in suckling hamsters accompanied by marked histologic changes. Ennis et al, (1969) found that both a high-passaged strain of mumps virus attenuated for man and a virulent, low-passaged virus cause hydrocephalus in hamsters when the viruses are inoculated intracerebrally. Kilham (1961) also found that rat virus (RV), while causing no apparent disease upon inoculation into rats, can cause three different manifestations of disease in suckling hamsters according to dose of virus and age of the animal at the time of inoculation, i.e., fatal disease in animals inoculated at 1-4 days of age, with stunted growth in any of these animals surviving a minimal dose, or latent infection following inoculation of older sucklings. Kilham further reported that various routes of inoculation were all equally effective in inducing acute disease, and that there was spontaneous trans¬ mission of RV from inoculated to uninoculated hamsters. The Syrian hamster has also been reported to be highly susceptible to the following viruses: St. Louis encephalitis (Broun et al., 1941, and Lennette, 1941), Japanese B encephalitis (Lennette, 1941), influenza (Taylor, 1940; Taylor and Parodi, 1942), lymphocytic choriomeningitis (Smadel and Wall, 1942), mare abortion (Anderson and Goodpasture, 1942), and a murine strain of poliomyelitis (Plotz, Regan, and Hamilton, 1942).

Comments

A Thesis submitted to the Faculty of the Graduate School, Marquette University, in Partial Fulfillment of the Requirements for the Degree of Master of Science Milwaukee, Wisconsin

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