Inward Rectification of the MinK Potassium Channel

Authors

Edward M. Blumenthal, Marquette UniversityFollow
Leonard K. Kaczmarek, Yale University

Document Type

Article

Language

eng

Format of Original

7 p.

Publication Date

10-1993

Publisher

Springer

Source Publication

The Journal of Membrane Biology

Source ISSN

0022-2631

Abstract

The minK protein induces a slowly activating voltage-dependent potassium current when expressed in Xenopus oocytes. We have used macroscopic minK currents to determine the open channel current-voltage relationship for the channel, and have found that the minK current is inwardly rectifying. The channel passes inward current at least 20fold more readily than outward current. Both rat and human minK exhibit this property. The rectification of minK is similar to that reported for a slow component of the cardiac delayed rectifier, strengthening the hypothesis that minK is responsible for that current.

Comments

The Journal of Membrane Biology, Vol. 136, No. 1 (October 1993): 23-29. DOI.

Edward Blumenthal was affiliated with the Yale University School of Medicine at the time of publication.

Recommended Citation

Blumenthal, Edward M. and Kaczmarek, Leonard K., "Inward Rectification of the MinK Potassium Channel" (1993). Biological Sciences Faculty Research and Publications. 216.
https://epublications.marquette.edu/bio_fac/216