Contractile Properties of Rat Soleus Muscle: Effects of Training and Fatigue

Document Type

Article

Language

eng

Publication Date

9-1977

Publisher

American Physiological Society

Source Publication

American Journal of Physiology: Cell Physiology

Source ISSN

0002-9513

Original Item ID

DOI: 10.1152/ajpcell.1977.233.3.C86

Abstract

The effects of exercise training and fatigue on the contractile properties of rat soleus muscles have been investigated. Prolonged exercise, consisting of 2 h or daily treadmill running, induced small but significant decrease in contraction time, one-half relaxation time, and maximum tetanic tension (Po), and increase in the peak rate of tension development (dP/dt) during a twitch, and an increase in maximum shortening velocity (Vmax). The 20% increase in Vmax was proportional to the previously reported increase in actomyosin ATPase induced by 2 h of daily running. These results indicate that prolonged training can induce modifications of the neurally determined contractile properties of skeletal muscle. To investigate the effects of fatigue, soleus muscles were stimulated in situ with 250-ms trains of 100 Hz at a rate of 110 trains per minute for 30 min. This resulted in a 32% decrease in Po, a 48% decline in peak tetanic dP/dt, and a 12% decrease in Vmax in muscles of untrained animals. Muscles that had adapted to exercise were significantly protected against the decrease in Po (only an 8% decrease) and Vmax (no significant decrease) but not against the decline in peak dP/dt.

Comments

American Journal of Physiology: Cell Physiology, Vol. 233, No. 3 (September 1977): C86-C91. DOI.

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