Effect of Exercise on Response of Liver Lipogenic Enzymes to a High Fructose Diet
Document Type
Article
Language
eng
Publication Date
4-1975
Publisher
SAGE Publications
Source Publication
Experimental Biology and Medicine
Source ISSN
1535-3702
Abstract
Meal-fed Long-Evans rats fed a high fructose diet and exercised for 2-hr daily on a treadmill for three days had lower levels of several hepatic lipogenic enzymes (acetyl CoA carboxylase, glucose-6-phosphate dehydrogenase, 6-phosphoglu-conate dehydrogenase, malic enzyme and citrate cleavage enzyme) than did sedentary rats pair-fed the diet. Accumulation of triglycerides in plasma following ingestion of a fat-free, high fructose meal and injection of Triton WR-1339, an inhibitor of plasma triglyceride clearance, was not significantly different in the two groups of animals.
All of the hepatic lipogenic enzymes measured, with the exception of citrate cleavage enzyme, attained similar levels in the runners as in the controls after 5 days on the high fructose diet. Thus the exercise appeared to affect the time course of the increase in the levels of activity of most of the lipogenic enzymes but not the final steady state levels attained.
Recommended Citation
Winder, W. W.; Booth, F. W.; Fitts, Robert H.; and Holloszy, J. O., "Effect of Exercise on Response of Liver Lipogenic Enzymes to a High Fructose Diet" (1975). Biological Sciences Faculty Research and Publications. 560.
https://epublications.marquette.edu/bio_fac/560
Comments
Experimental Biology and Medicine, Vol. 148, No. 4 (April 1975): 1150-1154. DOI.
Robert Fitts was affiliated with Washington University School of Medicine at the time of publication.