Evidence for a Common Mechanism for the Insertion of the Tn10 Transposon and for the Generation of Tn10-stimulated Deletions
Document Type
Article
Language
eng
Publication Date
1-1978
Publisher
Springer
Source Publication
Molecular and General Genetics MGG
Source ISSN
0026-8925
Abstract
Mutations in and near the Salmonella typhimurium histidine transport operon were generated by insertion of the translocatable tetracycline-resistance element Tn10. Deletion mutants affecting histidine transport genes were subsequently isolated in several of the Tn10-containing strains. Tn10 insertions in hisJ occurred preferentially at one site, designated site A. This same site was also the preferential endpoint of deletions originating from Tn10 insertions at two neighboring sites. Thus, Tn10 insertion and Tn10-stimulated deletion formation appear to involve a common DNA-recogition step.
Recommended Citation
Noel, K. Dale and Ames, Giovanna Ferro-Luzzi, "Evidence for a Common Mechanism for the Insertion of the Tn10 Transposon and for the Generation of Tn10-stimulated Deletions" (1978). Biological Sciences Faculty Research and Publications. 589.
https://epublications.marquette.edu/bio_fac/589
Comments
Molecular and General Genetics MGG, Vol. 166, No. 2 (January 1978): 217-223. DOI.