Document Type
Article
Language
eng
Publication Date
2-2015
Publisher
Springer
Source Publication
Diabetologia
Source ISSN
0012-186X
Abstract
Obesity is a growing health risk with few successful treatment options and fewer still that target both obesity and obesity-associated comorbidities. Despite ongoing scientific efforts, the most effective treatment option to date was not developed from basic research but by surgeons observing outcomes in the clinic. Bariatric surgery is the most successful treatment for significant weight loss, resolution of type 2 diabetes and the prevention of future weight gain. Recent work with animal models has shed considerable light on the molecular underpinnings of the potent effects of these ‘metabolic’ surgical procedures. Here we review data from animal models and how these studies have evolved our understanding of the critical signalling systems that mediate the effects of bariatric surgery. These insights could lead to alternative therapies able to accomplish effects similar to bariatric surgery in a less invasive manner.
Recommended Citation
Arble, Deanna M.; Sandoval, Darleen A.; and Seeley, Randy J., "Mechanisms Underlying Weight Loss and Metabolic Improvements in Rodent Models of Bariatric Surgery" (2015). Biological Sciences Faculty Research and Publications. 652.
https://epublications.marquette.edu/bio_fac/652
Comments
Accepted version. Diabetologia, Vol. 58, No. 2 (February 2015): 211-220. DOI. © 2015 Springer Nature Switzerland AG. Part of Springer Nature. Used with permission.
Deanna M. Arble was affiliated with the University of Michigan, Ann Arbor at the time of publication.
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