Stress Biology: Complexity and Multifariousness in Health and Disease
Document Type
Article
Publication Date
2024
Publisher
Elsevier
Source Publication
Cell Stress and Chaperones
Source ISSN
1355-8145
Original Item ID
DOI: 10.1016/j.cstres.2024.01.006
Abstract
Preserving and regulating cellular homeostasis in the light of changing environmental conditions or developmental processes is of pivotal importance for single cellular and multicellular organisms alike. To counteract an imbalance in cellular homeostasis transcriptional programs evolved, called the heat shock response, unfolded protein response, and integrated stress response, that act cell-autonomously in most cells but in multicellular organisms are subjected to cell-nonautonomous regulation. These transcriptional programs downregulate the expression of most genes but increase the expression of heat shock genes, including genes encoding molecular chaperones and proteases, proteins involved in the repair of stress-induced damage to macromolecules and cellular structures. Sixty-one years after the discovery of the heat shock response by Ferruccio Ritossa, many aspects of stress biology are still enigmatic. Recent progress in the understanding of stress responses and molecular chaperones was reported at the 12th International Symposium on Heat Shock Proteins in Biology, Medicine and the Environment in the Old Town Alexandria, VA, USA from 28th to 31st of October 2023.
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Recommended Citation
Sontag, Emily M., "Stress Biology: Complexity and Multifariousness in Health and Disease" (2024). Biological Sciences Faculty Research and Publications. 994.
https://epublications.marquette.edu/bio_fac/994
Comments
Cell and Stress Chaperones, Vol. 29, No.1 (2024): 143-157. DOI. Please see article for full author list.