Identification of MIMAS, a Multifunctional Mega-Assembly Integrating Metabolic and Respiratory Biogenesis Factors of Mitochondria
Document Type
Article
Publication Date
2024
Publisher
Elsevier
Source Publication
Cell Reports
Source ISSN
2639-1856
Original Item ID
DOI: 10.1016/j.celrep.2024.113772
Abstract
The mitochondrial inner membrane plays central roles in bioenergetics and metabolism and contains several established membrane protein complexes. Here, we report the identification of a mega-complex of the inner membrane, termed mitochondrial multifunctional assembly (MIMAS). Its large size of 3 MDa explains why MIMAS has escaped detection in the analysis of mitochondria so far. MIMAS combines proteins of diverse functions from respiratory chain assembly to metabolite transport, dehydrogenases, and lipid biosynthesis but not the large established supercomplexes of the respiratory chain, ATP synthase, or prohibitin scaffold. MIMAS integrity depends on the non-bilayer phospholipid phosphatidylethanolamine, in contrast to respiratory supercomplexes whose stability depends on cardiolipin. Our findings suggest that MIMAS forms a protein-lipid mega-assembly in the mitochondrial inner membrane that integrates respiratory biogenesis and metabolic processes in a multifunctional platform
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Recommended Citation
Stuart, Rosemary A., "Identification of MIMAS, a Multifunctional Mega-Assembly Integrating Metabolic and Respiratory Biogenesis Factors of Mitochondria" (2024). Biological Sciences Faculty Research and Publications. 999.
https://epublications.marquette.edu/bio_fac/999
Comments
Cell Reports, Vol. 43, No. 3 (2024). DOI. Please see article for full author list.