Document Type

Article

Language

eng

Format of Original

11 p.

Publication Date

7-2012

Publisher

Institute of Electrical and Electronics Engineers

Source Publication

IEEE Transactions on Biomedical Engineering

Source ISSN

0018-9294

Original Item ID

doi: 10.1109/TBME.2012.2196275

Abstract

Coronary stent design influences local patterns of wall shear stress (WSS) that are associated with neointimal growth, restenosis, and the endothelialization of stent struts. The number of circumferentially repeating crowns NC for a given stent de- sign is often modified depending on the target vessel caliber, but the hemodynamic implications of altering NC have not previously been studied. In this investigation, we analyzed the relationship between vessel diameter and the hemodynamically optimal NC using a derivative-free optimization algorithm coupled with computational fluid dynamics. The algorithm computed the optimal vessel diameter, defined as minimizing the area of stent-induced low WSS, for various configurations (i.e., NC) of a generic slotted-tube design and designs that resemble commercially available stents. Stents were modeled in idealized coronary arteries with a vessel diameter that was allowed to vary between 2 and 5 mm. The results indicate that the optimal vessel diameter increases for stent configurations with greater NC, and the designs of current commercial stents incorporate a greater NC than hemodynamically optimal stent designs. This finding suggests that reducing the NC of current stents may improve the hemodynamic environment within stented arteries and reduce the likelihood of excessive neointimal growth and thrombus formation.

Comments

Accepted version. IEEE Transactions on Biomedical Engineering, Vol. 59, No. 7 (July 2012): 1992-2002. DOI. © 2012 Institute of Electrical and Electronics Engineers (IEEE). Used with permission.

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