Reduction Potentials of Anthelmintic Drugs: Possible Relationship to Activity

Authors

Peter Kovacic, University of Wisconsin - MilwaukeeFollow
James R. Ames, University of Wisconsin - MilwaukeeFollow
Douglas L. Rector, The Upjohn Company, Kalamazoo, MI
Mikolaj Jawdosiuk, University of Wisconsin - Milwaukee
Michael D. Ryan, Marquette UniversityFollow

Document Type

Article

Language

eng

Format of Original

9 p.

Publication Date

1989

Publisher

Elsevier

Source Publication

Free Radical Biology and Medicine

Source ISSN

0891-5849

Abstract

Electrochemical data were acquired for several categories of anthelmintic agents, namely, iminium-type ions, metal derivatives and chelators, quinones and iminuquinones, and nitroheterocytes. Reductions usually were in the favorable range of +0.2 to −0.7 V versus normal hydrogen electrode. The drug effect is believed to result in part from either the catalytic production of oxidative stress or disruption of helminth electron transport systems. Relevant literature results are discussed.

Comments

Free Radical Biology and Medicine, Vol. 6, No. 2 (1989): 131-139. DOI.

Recommended Citation

Kovacic, Peter; Ames, James R.; Rector, Douglas L.; Jawdosiuk, Mikolaj; and Ryan, Michael D., "Reduction Potentials of Anthelmintic Drugs: Possible Relationship to Activity" (1989). Chemistry Faculty Research and Publications. 503.
https://epublications.marquette.edu/chem_fac/503