Reduction Potentials of Anthelmintic Drugs: Possible Relationship to Activity
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Free Radical Biology and Medicine
Electrochemical data were acquired for several categories of anthelmintic agents, namely, iminium-type ions, metal derivatives and chelators, quinones and iminuquinones, and nitroheterocytes. Reductions usually were in the favorable range of +0.2 to −0.7 V versus normal hydrogen electrode. The drug effect is believed to result in part from either the catalytic production of oxidative stress or disruption of helminth electron transport systems. Relevant literature results are discussed.