Conformational Analysis of 5,6-dihydropyrimidine and Its Derivatives
Russian Chemical Bulletin
The equilibrium geometry and inversion barriers of 5,6-dihydropyrimidine, 6,7-dihydroazolopyrimidines with node nitrogen atoms and their alkyl (Me, Et, Pri, But) and phenyl derivatives were calculated using a molecular mechanics approach. Annelation with azole cycles and the introduction of substituents have a slight effect on the equilibrium conformation of the dihydrocycle (distorted sofa). Alkyl substituents at saturated carbons have an essentially equatorial orientation in 5,6-dihydropyridimine derivatives and are axial in the annelated analogs. On the other hand, the equatorial conformers are more stable in phenyl derivatives of dihydroazolopyrimidines. Factors determining the relative stability of conformers were analyzed.
Shishkin, O. V.; Polyakova, A. S.; Desenko, S. M.; Orlov, D. V.; Lindeman, Sergey V.; and Struchkov, Yu T., "Conformational Analysis of 5,6-dihydropyrimidine and Its Derivatives" (1995). Chemistry Faculty Research and Publications. 651.