Document Type
Article
Language
eng
Publication Date
6-17-2020
Publisher
Dove Medical Press
Source Publication
International Journal of Nanomedicine
Source ISSN
1176-9114
Abstract
With the passage of time and more advanced societies, there is a greater emergence and incidence of disease and necessity for improved treatments. In this respect, nowadays, aptamers, with their better efficiency at diagnosing and treating diseases than antibodies, are at the center of attention. Here, in this review, we first investigate aptamer function in various fields (such as the detection and remedy of pathogens, modification of nanoparticles, antibiotic delivery and gene delivery). Then, we present aptamer-conjugated nanocomplexes as the main and efficient factor in gene delivery. Finally, we focus on the targeted co-delivery of genes and drugs by nanocomplexes, as a new exciting approach for cancer treatment in the decades ahead to meet our growing societal needs.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 3.0 License
Recommended Citation
Rabiee, Navid; Ahmadi, Sepideh; Arab, Zeynab; Bagherzadeh, Mojtaba; Safarkhani, Moein; Nasseri, Behzad; Rabiee, Mohammad; Tahriri, Mohammadreza; Webster, Thomas J.; and Tayebi, Lobat, "Aptamer Hybrid Nanocomplexes as Targeting Components for Antibiotic/Gene Delivery Systems and Diagnostics: A Review" (2020). School of Dentistry Faculty Research and Publications. 399.
https://epublications.marquette.edu/dentistry_fac/399
Comments
Published version. International Journal of Nanomedicine, Vol. 15 (June 17, 2020): 4237-4256. DOI. © 2020 Dove Medical Press. Used with permission.