Carbosilane Dendrimers: Drug and Gene Delivery Applications

Authors

Navid Rabiee, Sharif University of Technology
Shokooh Ahmadvand, Islamic Azad University
Sepideh Ahmadi, Shahid Beheshti University of Medical SciencesFollow
Yousef Fatahi, Tehran University of Medical Sciences
Rassoul Dinarvand, Tehran University of Medical Sciences
Mojtaba Bagherzadeh, Sharif University of Technology
Mohammad Rabiee, Amirkabir University of Technology
Mohammadreza Tahriri, Marquette UniversityFollow
Lobat Tayebi, Marquette UniversityFollow
Michael R. Hamblin, Massachusetts General Hospital

Document Type

Article

Publication Date

10-2020

Publisher

Elsevier

Source Publication

Journal of Drug Delivery Science and Technology

Source ISSN

1773-2247

Abstract

Carbosilane dendrimers are a particular type of dendrimer structure that has been used as delivery vehicles for drugs and nucleic acids. They have a defined structure according to their generation number, and their terminal groups can be rendered cationic or anionic. The cationic charges can address the limitation of electrostatic repulsion between the negatively charged phosphate groups of nucleic acids and negatively charged cell membranes. Specific drugs can be loaded into the central part of the dendrimer or attached at the exterior, and the overall positive charge may improve the efficacy of anti-inflammatory drugs. One promising feature of dendrimers is their non-toxicity both in vitro and in vivo up to therapeutic concentrations. Carbosilane dendrimers display good biocompatibility and can be used for anti-HIV, anti-viral, and anti-inflammatory applications, as well as for delivery of nucleic acids for anti-cancer therapy.

Comments

Accepted version. Journal of Drug Delivery Science and Technology, Vol. 59 (October 2020): 101879. DOI. © 2020 Elsevier. Used with permission.

Recommended Citation

Rabiee, Navid; Ahmadvand, Shokooh; Ahmadi, Sepideh; Fatahi, Yousef; Dinarvand, Rassoul; Bagherzadeh, Mojtaba; Rabiee, Mohammad; Tahriri, Mohammadreza; Tayebi, Lobat; and Hamblin, Michael R., "Carbosilane Dendrimers: Drug and Gene Delivery Applications" (2020). School of Dentistry Faculty Research and Publications. 445.
https://epublications.marquette.edu/dentistry_fac/445