Date of Award


Document Type


Degree Name

Doctor of Philosophy (PhD)



First Advisor

John Paul Kampine


This study originated as a study of the effects of hypoxia and of various pharmacological agents on the pulmonary vasculature of the left lower lobe of the canine lung. Because the bronchomotor tone might also be affected, particularly by the pharmacological agents, it was decided as a secondary objective to also measure the effects of these agents on bronchomotor tone. It quickly became apparent that this was not as simple as it sounded. As no totally satisfactory method existed, a method of studying pulmonary mechanics in the left lower lobe in situ had to be developed. The effects of pump perfusion, hypocapnia, hypoxia, and pulmonary blood flow on pulmonary resistance and lung compliance in themselves were ill defined . The literature contains numerous references to such words as hence and presumably, as well as some outright contradictory observations. Thus the study slowly developed into an investigation of the local control of pulmonary resistance and lung compliance in the left lower lobe of the dog.