Conjugated Linoleic Acid Preserves Muscle Mass in Mice Bearing the Lewis Lung Carcinoma, but not the B16 Melanoma

Document Type

Article

Language

eng

Publication Date

4-2006

Publisher

Wiley

Source Publication

Research in Nursing and Health

Source ISSN

0160-6891

Original Item ID

DOI: 10.1002/nur.20115

Abstract

Conjugated linoleic acid (CLA), which is found in dairy products, reduces synthesis of tumor necrosis factor-alpha (TNFa), a pro-inflammatory cytokine that plays a major role in tumor-induced skeletal muscle wasting (SMW). The B16 melanoma expresses TNFa mRNA, and induced SMW with no change in muscle levels of TNFa type 1 receptor (TNFR1) protein. A diet containing .5% CLA had no effect on SMW or TNFR1 in mice bearing B16 tumors. In contrast, the Lewis lung carcinoma expresses low levels of TNFa mRNA, induced SMW, and increased muscle levels of TNFR1. A diet containing .5% CLA reduced SMW, but had no effect on muscle levels of TNFR1. We conclude that that tumor-induced SMW can occur independent of muscle levels of TNFR1. Further study is needed before CLA can be tested in persons with cancer cachexia.

Comments

Journal in Nursing and Health, Vol. 29, No. 2 (April 2006): 98-104. DOI.

Donna McCarthy was affiliated with the National Institute of Nursing Research at the time of publication.

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