Peripheral Blood Pressure Changes Induced by Dobutamine Do Not Alter BOLD Signals in The Human Brain
Document Type
Article
Language
eng
Publication Date
4-15-2006
Publisher
Elsevier
Source Publication
NeuroImage
Source ISSN
1053-8119
Abstract
In extending the use of functional MRI to neuropharmacology, a primary area of concern is that peripheral blood pressure changes induced by pharmacological agents could independently produce a change in the blood oxygenation level-dependent (BOLD) signal, resulting in difficulties distinguishing or interpreting drug-induced neural activations. In the present study, we utilized intravenous dobutamine, a beta-adrenergic receptor agonist, to increase the mean arterial blood pressure (MABP), while examining the effects of MABP changes on the BOLD signal in cocaine-dependent participants. Dobutamine infusion significantly increased the MABP from 93 ± 8 mm Hg to 106 ± 12 mm Hg (P < 0.0005), but did not produce a significant global BOLD signal. Yet, a few voxels in the anterior cingulate showed BOLD signal changes that paralleled the changes in blood pressure (BP). Our observations support the conclusion that following the infusion of psychoactive agents, brain BOLD signals accurately reflect neuronal activity, even in the face of relatively large peripheral cardiovascular effects that transiently increase systemic BP.
Recommended Citation
Liu, Heng; Rainey, Charles; Lauer, Kathryn K.; Piacentine, Linda B.; Bloom, Alan S.; Risinger, Robert C.; Ward, B. Douglas; Stein, Elliot; and Li, Shi-Jiang, "Peripheral Blood Pressure Changes Induced by Dobutamine Do Not Alter BOLD Signals in The Human Brain" (2006). College of Nursing Faculty Research and Publications. 681.
https://epublications.marquette.edu/nursing_fac/681
Comments
Accepted version. NeuroImage, Vol. 30, No. 3 (April 15, 2006): 745-752. DOI. This article is © Elsevier. Used with permission.
Linda Piacentine was affiliated with Medical College of Wisconsin at the time of publication.