Document Type
Article
Publication Date
12-2023
Publisher
Wiley
Source Publication
Psychophysiology
Source ISSN
0048-5772
Original Item ID
DOI: 10.1111/psyp.14395
Abstract
The apolipoprotein-E (APOE) ε4 allele is the greatest genetic risk factor for late-onset Alzheimer's disease (AD), but alone it is not sufficiently predictive. Because neuropathological changes associated with AD begin decades before cognitive symptoms, neuroimaging of healthy, cognitively intact ε4 carriers (ε4+) may enable early characterization of patterns associated with risk for future decline. Research in the cerebral cortex highlights a period of compensatory recruitment in elders and ε4+, which serves to maintain cognitive functioning. Yet, AD-related changes may occur even earlier in the cerebellum. Advances in electroencephalography (EEG) source localization now allow effective modeling of cerebellar activity. Importantly, healthy aging and AD are associated with declines in both cerebellar functions and executive functioning (EF). However, it is not known whether cerebellar activity can detect pre-symptomatic AD risk. Thus, the current study analyzed cerebellar EEG source localization during an EF-dependent stop-signal task (i.e., inhibitory control) in healthy, intact older adults (Mage = 80 years; 20 ε4+, 25 ε4−). Task performance was comparable between groups. Older age predicted greater activity in left crus II and lobule VIIb during the P300 window (i.e., performance evaluation), consistent with age-related compensation. Age*ε4 moderations specifically showed that compensatory patterns were evident only in ε4−, suggesting that cerebellar compensatory resources may already be depleted in healthy ε4+ elders. Thus, the posterolateral cerebellum is sensitive to AD-related neural deficits in healthy elders. Characterization of these patterns may be essential for the earliest possible detection of AD risk, which would enable critical early intervention prior to symptom onset.
Recommended Citation
Paitel, Elizabeth and Nielson, Kristy A., "Cerebellar EEG Source Localization Reveals Age-Related Compensatory Activity Moderated by Genetic Risk for Alzheimer’s Disease" (2023). Psychology Faculty Research and Publications. 589.
https://epublications.marquette.edu/psych_fac/589
Comments
Accepted version. Psychophysiology, Vol. 60, No. 12 (December 2023). DOI. © 2023 Wiley. Used with permission.