Document Type
Article
Language
eng
Publication Date
8-6-2018
Publisher
Frontiers Media, S.A.
Source Publication
Frontiers in Endocrinology
Source ISSN
1664-2392
Abstract
Obstructive sleep apnea (OSA) is a common sleep disorder, effecting 17% of the total population and 40–70% of the obese population (1, 2). Multiple studies have identified OSA as a critical risk factor for the development of obesity, diabetes, and cardiovascular diseases (3–5). Moreover, emerging evidence indicates that metabolic disorders can exacerbate OSA, creating a bidirectional relationship between OSA and metabolic physiology. In this review, we explore the relationship between glycemic control, insulin, and leptin as both contributing factors and products of OSA. We conclude that while insulin and leptin action may contribute to the development of OSA, further research is required to determine the mechanistic actions and relative contributions independent of body weight. In addition to increasing our understanding of the etiology, further research into the physiological mechanisms underlying OSA can lead to the development of improved treatment options for individuals with OSA.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Framnes, Sarah N. and Arble, Deanna M., "The Bidirectional Relationship Between Obstructive Sleep Apnea and Metabolic Disease" (2018). Biological Sciences Faculty Research and Publications. 657.
https://epublications.marquette.edu/bio_fac/657
Comments
Published version. Frontiers in Endocrinology, Vol. 9, No. 440 (August 6, 2018). DOI. © 2018 Framnes and Arble. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.