"A Study of the Factors Affecting the Validity of the Indicator Dilutio" by Leonard F. Rozek
 

Date of Award

7-1961

Degree Type

Master's Essay - Restricted

Degree Name

Master of Science (MS)

Department

Medical

First Advisor

William J. Stekiel

Second Advisor

James J. Smith

Third Advisor

William Held

Abstract

The measurement of blood flow in the body, both peripheral and central, has been a challenge to physiologists since the discovery of the circulatory system. Various methods or volume flow measurements have been and are being developed, not only to gain knowledge of these values under normal physiological conditions, but to evaluate changes which take place in these values under pathological conditions. These methods or measurement are usually placed into two classifications; direct and indirect. It could be argued that neither actually measures physiological blood flow. The direct methods are more satisfying to the investigator, but involve a physical intervention into the blood flow which one is attempting to measure. There is also considerable surgical manipulation involved in the direct methods which have a questionable effect on the true flow. The indirect methods, such as the indicator-dilution technique, are based on measurement of a variable related to the blood flow. This relationship between the measured variable and flow rate may or may not remain constant due to practical considerations which force violations or the basic assumptions. Realization of this led to an investigation of the errors which are introduced in the actual application of the indicator-dilution method.

Comments

A thesis submitted to the faculty of the Graduate School, Marquette University in partial fulfillment of the requirements for the degree of Master of Science in Physiology, Milwaukee, Wisconsin.

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